Treating testes early may prevent male infertility

Treating testes early may prevent male infertility

Infertility is probably the last thing on teenage boys' minds. However, a new study out of Brazil suggests that early treatment of a common testicular condition could preserve future fatherhood potential for some adolescents.

A varicocele is a widening of the veins in the scrotum, which house the testicles. While frequently harmless, varicoceles can cause pain, testicular shrinkage and, over time, can potentially lead to lower sperm counts and quality.

The condition, which is similar to varicose veins, is estimated to affect 15 percent of men over 15. But it is found in more than a third of men being assessed for primary infertility -- an inability to biologically father a child -- and 80 percent of secondary infertility cases -- men who were once able to father a child but are not able to do so anymore.

Although varicoceles may not be the sole cause of infertility in all those cases, the close association with infertility and apparent worsening of the effect over time suggest early surgical correction of the flawed veins could have important benefits later on, the authors note.

"Because varicocele is a progressive disease, we want to know how soon we can intervene, especially because it does not cause infertility in all men," researcher Paula Toni Del Giudice of Sao Paulo Federal University, in Brazil, told Reuters Health in an e-mail. "Surgical intervention is not for everyone."

Del Giudice and her colleagues studied 21 boys between the ages of 15 and 19. They collected two semen samples before surgical correction of the varicoceles and another two samples at least three months after the varicocelectomy.

The team reports in the journal Fertility and Sterility that two important indicators of the sperm's functional health -- the integrity of the sperm cells' DNA and the activity of internal energy generators called mitochondria -- significantly improved after the surgery.

"Surgical intervention in adolescents indicated for varicocelectomy does improve sperm functional traits that are associated with infertility in adults, so there is an important benefit in performing this surgery," said Del Giudice.

The decision of whether or not to proceed with a varicocelectomy is typically based on testicular volume, or how much smaller the affected testicle is compared to the other, as well as a conventional analysis of semen quantity and quality.

The new study's additional measures of sperm damage "could represent another consideration when counseling patients and parents on whether to perform," Dr. Eric Seaman of the Urology Group of New Jersey, in West Orange, told Reuters Health.

Further, the surgery poses very little risk, according to Seaman, aside from the possibility of bleeding or infection that comes with any surgery. There is a small chance that a patient could also experience some uncomfortable post-operative fluid retention around the testicle, he said.

The total costs of undergoing a varicocelectomy, including hospital services and anesthesia, runs a few thousand dollars and is typically covered by insurance.

Still, Seaman does not suggest that parents need to rush their teenage sons into surgery. "If it sits a month, nothing will happen," he said. "A year could be another story."

"We feel that all young boys should be referred to an urologist for a full clinical evaluation, just as girls are referred to their gynecologists," added Del Giudice. "Not all adolescents will have a varicocele, and not all adolescents with a varicocele will need an operation."

Article: Fertility and Sterility, Nov 2010

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Posted: 25/11/2010 14:32:56


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