"Fertility MOTs" not a reliable predictor of ability to conceive, study shows

10/10/2017

"Fertility MOTs" not a reliable predictor of ability to conceive, study shows

"Fertility MOTs" marketed at women who fear they have left it too late to have a baby are a waste of money, research suggests.

 

A new study found the results of the popular ovarian reserve tests - which are designed to tell women how many eggs they have left and their quality - had no bearing on whether women went on to conceive. 

The tests, which can cost a few hundred pounds are offered at fertility clinics across the UK as a way of predicting response to fertility treatment.

They are also marketed as "Fertility MOTs" for women concerned they may be leaving it too late to have a baby.

The new study, from the University of North Carolina and published in the Journal of the American Medical Association (JAMA), examined whether the biomarkers of ovarian reserve used in tests were linked to ability to conceive.

The biomarkers included early-follicular-phase serum antimullerian hormone (AMH) and serum follicle-stimulating hormone (FSH), which are commonly used in UK tests.

The study was among 750 women aged 30 to 44 years without a history of infertility who had been trying to conceive for three months or less.

The results showed that low AMH or high FSH had no bearing on the chance of a woman falling pregnant within any given month, and did not lead to a lower chance of conceiving after six or 12 months.

The researchers said: "Among women aged 30 to 44 years without a history of infertility who had been trying to conceive for three months or less, biomarkers indicating diminished ovarian reserve compared with normal ovarian reserve were not associated with reduced fertility.

"These findings do not support the use of urinary or blood follicle-stimulating hormone tests or antimullerian hormone levels to assess natural fertility for women with these characteristics." 

Dr Meenakshi Choudhary from Newcastle upon Tyne Hospitals NHS Trust said: "This study further affirms the belief that 'one size fits all' fertility MOT is not a universal formula for those with sub-fertility and those without.

"One must administer caution before performing and interpreting ovarian reserve marker tests (designed as a tool for subfertility and assisted conception management) for those who do not have any concerns with fertility."

Dr Channa Jayasena, clinical senior lecturer at Imperial College London, said: "Hormone levels change with time, so taking a snapshot today tells us very little about what women's fertility will be like tomorrow.

"This study tells us that measuring these hormones to predict fertility in potentially worried and vulnerable women is wrong, and should be stopped."

Article source: www.telegraph.co.uk 10th October 2017

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